Canespro® Once Daily is a product containing bifonazole, which is a more convenient treatment. Apply only once daily for 2-3 weeks compared to conventional antifungal medications. Fungal infections are sometimes co-infected by bacterial infections and inflammation. Canespro® Once Daily has the ability to kill gram-positive bacteria (such as Corynebacterium minutissimum) and reduce inflammation. ^[1-4]

References:

1. Plempel M et al. Spinger-Verlag, 4-20
2. Petri HT, et al. Advances in topical antifungal therapy, 1986: 26-31
3. Hube B, et al. Journal de mycologie medicale. 2015;25(1):e44-58.
4. Canespro® Once Daily Local Indications

Studies in healthy volunteers have shown that bifonazole produces an effect equivalent to 1% hydrocortisone, in reducing wheal and flare responses to intracutaneous histamine, and in decreasing UV-induced erythema. ^[1-3] Bifonazole have also been shown to inhibit keratinase, an enzyme that stimulates inflammation.

References:

1. Petri H et al. Advances in Topical Antifungal Therapy;1986.
2. Huth L et al. Skin Pharmacol Physiol 2019;32:337–343.
3. M Schaller et al.Mycoses. 2016 Jun;59(6):365-73.

Bifonazole has a lipopholic profile and provides better skin absorption than clotrimazole leading to higher amount in skin. In a comparative study of bifonazole and clotrimazole absorbed into the skin, bifonazole concentrations in all layers were approximately 1 times greater than those of clotrimazole.^[1]

In addition, when about 6000 patients with fungal infections were treated with bifonazole cream once a day for each type of fungal infection, efficacy was more than 90%.^[2]

References:

1. Lucker PW et al. Dermatologica 169;suppl. 1, 1984: 51-6
2. Saffe F, et al. Advances in topical antifungal therapy, 1986: 53-64

Bifonazole can inhibit 2 steps of ergosterol biosynthesis while other azoles inhibit only 1 step. Bifonazole also rapidly penetrates the skin layer within 30 minutes and last up to 120 hours. ^[1]

References:

1. Plempel M et al. Spinger-Verlag, 4-20

There is no need because Bifonazole rapidly penetrates the skin layer within 30 minutes and last up to 120 hours. ^[1]

References:

1. Plempel M et al. Spinger-Verlag, 4-20

Yes, Canespro can be used to treat Athlete’s Foot, Ringworm and Jock Itch. Please refer to Patient Information Leaflet for each fungal treatment duration.

Reference:

1. Canespro® Once Daily Local Indications