Canespro Bifonazole Produc

What is Canespro® Once-Daily?

Are you looking for a fungal infection cream that is convenient and works effectively? Canespro® Once-Daily is an antifungal cream used to treat a broad spectrum of fungal skin infections including athlete’s foot, ringworm and jock itch.

Bifonazole is the active ingredient in Canespro® Once-Daily. With bifonazole, you only need to apply the cream once a day. It also has a short duration of treatment, dealing with athlete’s foot in 3 weeks, ringworm and jock itch in 2-3 weeks, and white spot in 2 weeks. Please refer to the product information leaflet for more information.

Needing to apply cream only once a day is very convenient, especially if you’re busy, and likely to forget, or run out of time to apply your fungal cream. This also makes it easier to stick to your treatment plan for the full duration. Stopping your treatment prematurely, even if your symptoms have begun to disappear, makes your fungal infection symptoms more likely to recur.

A study with over six thousand patients showed just how effective this ingredient is. Results showed 90% efficacy with just once-a-day use of bifonazole for a variety of different fungal infections1.

Compared to other compounds in the category of antifungal agents known as azoles, bifonazole is better able to fight off skin flares and certain bacterial co-infections. Despite being an anti-inflammatory without steroid, bifonazole has also been found to have comparable effects to 1% hydrocortisone.2

What is the mode of action of bifonazole?

Bifonazole kills fungal infections. It penetrates infected skin within 20-30 minutes, and remains in the fungal cell for up to 120 hours. While in the fungal cell, it continuously disrupts the function and structure of its membrane. 3

Bifonazole is also able to inhibit an enzyme called keratinase, which stimulates inflammation. This helps reduce swelling and itchiness.

All these mechanisms and properties of bifonazole working together are how Canespro® Once-Daily is able to stop fungal growth, kill fungi and soothe itching.

Why is bifonazole indicated as once-daily?

Research found that a higher concentration of bifonazole stayed in the skin even hours after application, compared to clotrimazole4. A higher quantity of the antifungal compound penetrating into the skin per application means less total applications needed to achieve the same result.

Because of this, using Canespro® Once-Daily as indicated once a day is enough to rid oneself of the symptoms of fungal infection and keep it from coming back.

One study1 found that many patients reduce the frequency of applying their medication without being advised to do so, while others don’t even pay attention to the instructions on how often to apply their fungal infection cream. With a reduced need for applications and fast treatment time, Canespro® Once-Daily will benefit those seeking relief from their fungal woes.

How is bifonazole better than the current marketed azole products?

Bifonazole outperforms other azole antifungal creams in Singapore in a number of areas. It features:

  • Double-step inhibition of ergosterol biosynthesis
  • Higher concentration penetrating into the skin
  • Once-daily application
  • Short duration of treatment (2-4 weeks)
  • Anti-inflammatory without steroid

All these go toward ease of use and the effective resolution of fungal conditions for patients, many of whom have fast-paced lifestyles, and may at times view their course of treatment as a hassle.

Athlete’s foot, jock itch, ringworm, are unsightly, unpleasant, and can get in the way of daily activities. It’s a huge sigh of relief to know that you can use Canespro® Once-Daily just once a day during the treatment period to get rid of your symptoms.

If you have been diagnosed with any of these skin conditions, learn more about using Canespro® Once-Daily to treat the symptoms and the source in the next article: Bifonazole Treatment.


  1. 1 Saffé F. (1986) Bifonazole in Dermatological Practice: Results of a Multicentre Study. In: Hay R.J. (eds) Advances in Topical Antifungal Therapy. Springer, Berlin, Heidelberg.
  2. 2 Huth, L., Marquardt, Y., Heise, R., Fietkau, K., Becker, N. H., Huth, S., & Baron, J. M. (2019). Bifonazole Exerts Anti-Inflammatory Effects in Human Three-Dimensional Skin Equivalents after UVB or Histamine Challenge. Skin pharmacology and physiology, 32(6), 337–343.
  3. 3 Plempel M., Berg D., Ritter W. (1986) Bifonazole, a New Topical Azole Antimycotic with Specific Properties. In: Hay R.J. (eds) Advances in Topical Antifungal Therapy. Springer, Berlin, Heidelberg.
  4. 4 Lücker, P. W., Beubler, E., Kukovetz, W. R., & Ritter, W. (1984). Retention time and concentration in human skin of bifonazole and clotrimazole. Dermatologica, 169 Suppl 1, 51–55.